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The scientists discovered that in obese mice, a once-weekly dose of prednisone increased the amount of a signaling molecule that adipose tissue produces

This intermittent use pattern, while not extensively studied, may provide a practical approach for individuals who cannot afford or tolerate continuous long term treatment

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Clinical trial data supports safety for at least 2 years with semaglutide and 72 weeks with tirzepatide, with ongoing studies examining longer durations