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Silencing phospholipid scramblase 1 expression by RNA interference in colorectal cancer and metastatic liver cancer

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The resulting reactive oxygen species (ROS) activate the Apoptosis Signal-regulating Kinase 1 (ASK1)-c-Jun N-terminal Kinase (JNK)/p38 pathway, inducing DNA damage and mitochondrial membrane permeability transition (MPT) 49