retatrutide glp-1 retatrutide and the Grey Market: Buyer Beware – Sarah Hormachea Unapproved weight loss drug retatrutide

May be associated with centrilobular necrosis

We'll beat it

MCH1R antagonists have also been shown to be efficacious in animal models of depressive behavior although the precise mechanism for the antidepressant effects are not yet clearly defined

Authors Note This piece builds on my ongoing coverage of the intersection of health, technology, and capital from the GLP-1 economy reshaping American medicine to the rise of longevity as a new asset class

DAMPs also impact Kupffer cells, activating the nucleotide-binding oligomerization domain-like receptor (NLR) Family, Pyrin Domain-Containing 3 protein (NLRP3), a type of inflammasome leading to IL-1 secretion and inflammation, and pyroptosis, releasing more DAMPs and perpetuating a destructive cycle (Peiseler et al., 2022)

showed that obesity in patients with T1D is associated with an increased risk of chronic kidney disease (CKD) compared with T2D (23)