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Off-label use of Ozempic purely for weight loss in Hashimoto's patients without diabetes is not supported by current evidence or guidelines

Tran HT, Heeke S, Sujit S, Vokes N, Zhang J, Aminu M, Lam VK, Vaporciyan A, Swisher SG , Godoy MCB, Cascone T, Sepesi B, Gibbons DL, Wu J, Heymach JV

Studies examining long-term human use of this peptide dont currently exist, leaving questions about extended-use safety unanswered

Ishiko et al

Notably, glucagon-like peptide-1 receptor agonists (GLP-1RAs) can potentiate the activity of DMH GLP-1R neurons

Given that previous studies have implicated transcriptional CDKs (e.g., CDK7, CDK9, CDK12/13) in SF3B1 phosphorylation 75,76,77,78,79 , we compared the effects of their inhibition with OTS964