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Goyal MS, Venkatesh S, Milbrandt J, Gordon JI, Raichle ME

While 20th century medical solutions for weight loss were marred by withdrawals, failures and death, surgical methods found success

The team presented their research findings at the Pharmacy Quality Alliance 2024 Annual Meeting

But suffice it to say the compound rapamycin was identified first long before a really amazing guy named David Sabatini as a PhD student at Hopkins in 1993, 1994 as a side project in a lab made the discovery that this thing, rapamycin, was actually working by inhibiting a protein complex of which TOR, target of rapamycin, as it became named was the central piece

The transcription factor optomotor-blind antagonizes Drosophila haltere growth by repressing decapentaplegic and hedgehog targets

Thats where side effects come in and spoiler: theyre usually temporary, manageable , and totally worth riding out