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6-8 This compound is being evaluated in AML and myelodysplastic syndromes (MDS) with TP53 mutations and appears to be highly effective against this poor prognosis disease

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In a typical encapsulation experiment, PLGA nanoparticles exhibited a hydrodynamic diameter of 170 30 nm (z-average, PDI = 0.162) as measured using dynamic light scattering with anionic effective surface charge (20.5 5.3 mV) due to the terminal carboxylate groups on the PLGA polymers

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