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A pleiotropic missense variant in SLC39A8 is associated with Crohns disease and human gut microbiome composition

It takes years

Tao et al., 2008

10.1590/s1806-83242010000400013 Braz

For this reason, it is used to improve cognitive functions (such as attention and memory) in individuals or to modulate abnormal brain functions in ASD, epilepsy and other neurological disorders [73]

Understanding both PK and PD, helps estimate the exposure levels likely to be efficacious and the exposure levels that might induce side effects in humans

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