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Potential areas of expansion include: Cardiovascular outcomes: A dedicated CVOT, if not already required as a post-marketing commitment, would evaluate whether orforglipron reduces MACE in patients with established cardiovascular disease or high cardiovascular risk, following the precedent set by the SELECT trial for semaglutide

According to FDA prescribing information and clinical trial data, the most common adverse reactions include nausea, diarrhea, vomiting, constipation, abdominal pain, and decreased appetite

Early clinical studies have shown that mazdutide can induce significant weight loss alongside improvements in glycemic control and lipid metabolism

No medical, diagnostic, or therapeutic applications

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The first 4 weeks involve dose titration with modest early weight loss as the body adjusts