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117 Research has shown that polyphenols exert their anti-inflammatory effects by affecting the expression of genes responsible for proinflammatory cytokines, lipoxygenase, nitric oxide synthase, and cyclo-oxygenase

Preclinical data indicate modulation of inflammatory and pro-fibrotic signalling pathways relevant to lung fibrosis, yet direct demonstration of reduced fibroblast activation or collagen deposition in established pulmonary fibrosis models is currently lacking

The currently recruiting Phase 2 hamstring-strain trial is the clearest marker to watch for the first controlled human data

SY: Conceptualization, Funding acquisition, Methodology, Writing review & editing

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