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Moreover, most clinical cancer therapies, including conventional chemotherapies 8 , radiotherapy 9 , or recent immune therapies 10,11 , have also been reported to undermine female fertility in various ways, which further distracts researchers attention on NRTP-induced ovarian damage

Cyanocobalamin is a form of vitamin B12 used to treat or prevent B12 deficiency, which can result from dietary limitations, certain types of anemia, pregnancy, gastrointestinal disorders, or other medical conditions

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Cayman, 36209) and 20 mM of the transpeptidation acceptor glycyl-glycine (Sigma-Aldrich, G1002) in Tris-HCl 100 mM, pH 8, buffer