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Detrusor overactivity (DO) is seen in approximately 12-20% of IC/BPS patients

Similarly to asthma, mast cells, Th2 cells, basophils, and epithelial cells synthesize and release cytokines and chemokines (IL-3, IL-4, IL-5, IL-10, IL-13, GM-CSF, and RANTES), which are responsible for sustaining allergic inflammation and the associated oxidative/nitrosative stress (116118)

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GHK-Cu is a naturally occurring copper-binding tripeptide with the molecular formula CHCuNO and a molecular weight of approximately 340.9 g/mol

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