GLP-1 primarily acts by binding to the GLP-1 receptor (GLP-1 R), which is expressed in various tissues, including the heart, lungs, intestines, bones, and brain
Real-world use introduces variables that trials do not always capture
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Drugs and products mentioned included over-the-counter (OTC) weight-loss medicine orlistat, which was mentioned five times, and glucagon-like peptide-1 receptor agonist (GLP-1 RAs) Mounjaro (tirzepatide
In South Africa, these medicines remain largely inaccessible given their high costs, despite the large public health need for effective treatments for diabetes and obesity
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