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A digital space to be built in collaboration with local communities, in which to identify - also through virtual interaction between user-space and users - shared strategies for the protection, valorisation and promotion of cultural heritage and to foster the exchange of ideas between stakeholders (private individuals, public decision-makers and inhabitants)

Authors contributions Izadora Fernanda Veiga De Jesus Costa: Study concept and design

While selection and safety establish who to treat and how to minimize risks, response biomarkers evaluate whether the intervention produces meaningful benefit, mirroring how preclinical glial modulation must be validated through functional readouts