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Resveratrol may additionally activate the cells endogenous antioxidant responses via the Nrf2 pathway: there is evidence that resveratrol can promote Nrf2 release from Keap1 and its translocation to the nucleus, where Nrf2 induces the expression of detoxifying and antioxidant enzymes (50)

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10.1016/j.stem.2009.02.013 [DOI] [PubMed] [Google Scholar] 63.Wang W, Choi BK, Li W, Lao Z, Lee AY, Souza SC, et al

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For example, in cells expressing an active Rab37 mutant, knockdown of ATG5/7 not only reduces autophagic flux but also diminishes tissue inhibitor of metalloproteinase 1 secretion, leading to suppressed lung nodule formation and metastasis (68)