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SSTR1-5, somatostatin receptor subtypes 1-5

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Doctors usually start patients on a low dose and slowly increase it to help reduce side effects

When glutathione synthesis is inhibited, total S assimilation and incorporation into Cys are enhanced in sir1 cad2 relative to sir1

Future research should clarify the target selectivity to overcome this sensitivity gap, evaluate in vivo mammalian toxicity and assess the combined drug potential of each derivative to determine clinical transformation feasibility