While oral supplements can be effective for some, they may not provide the quick boost or high absorption rates needed for people with more significant deficiencies
A 12-week randomized trial demonstrated: Average weight loss of 2.6 kg in AOD-9604 group (1 mg/day) versus 0.8 kg in placebo group Preferential reduction in abdominal and visceral fat deposits No adverse effects on carbohydrate metabolism or insulin sensitivity Non-dose-dependent effects, with higher doses (10 mg/day) producing less weight loss than lower doses However, a subsequent 24-week Phase III trial with 502 subjects incorporating intensive diet and exercise showed no statistically significant weight loss compared to placebo, leading to development termination in 2007
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The researchers compared the three primary B12 delivery methods and found the following mean increases in serum B12 levels: A p-value of 0.270 means there is no statistically meaningful difference between the three methods
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It is listed as a rare adverse reaction in UK product information for both oral and injectable B12 preparations, and most people tolerate B12 supplements well even at high doses