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Other possible causes of lazy bowel syndrome include: Excessive methane produced by colon bacteria: IBS-C (IBS-constipation type) is associated with bacteria that produce methane, which can slow motility and possibly contribute to constipation 18 19

Psychiatric improvements were also observed, with an overall 16% improvement in life satisfaction (MANSA Quality of Life), 34% improvement in Clinical Global Impression, 25% reduction in depressive symptoms on patient health questionnaire and 28% reduction in sleep quality with Pittsburgh Sleep Quality Index [15,89]

Quick Answer: Pain at the semaglutide injection site occurs in approximately 1.2-1.4% of patients and typically results from tissue distension, preservative irritation, and injection technique factors