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The difference here is that these are unapproved peptides and ones that haven't been rigorously studied for safety and efficacy in the way that those prior peptides have been

most monogenic causes of hypertension affect renal salt handling and its regulation, although monogenic forms that affect the vasculature have also been identified

Cao R, Taylor Elrod L, Lehane RL, Kim E, Karlin KD

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Factors that promote inflammation or reduce anti-inflammatory mechanisms may however, predispose susceptible individuals to CSU