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10.1016/j.bios.2004.08.032 88 RamanaviciusA.RamanavicieneA

Acetaminophen- induced hepatic necrosis

When NNMT activity is elevated as documented in obese adipose tissue, several cancer types, and aged skeletal muscle intracellular NAD+ availability decreases, SAM availability decreases, and downstream sirtuin activity (particularly SIRT1 and SIRT3) is reduced

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Investigational medicines are not approved unless specifically stated by regulators

Results A total of 20 studies, encompassing 44 independent experiments and involving 1019 animals, were included in the analysis