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A comprehensive MEDLINE and CENTRAL databases search for DPP4 inhibitors, GLP1 receptor agonists, and SGLT2 inhibitor RCTs, which reported adverse effects, including seizures and epilepsy on clinicaltrials.gov, yielded 413 studies

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Future development directions Continuous AI progress and emergence of new algorithms In recent years, AI has moved beyond basic research and begun to influence clinical practice in the field of depression, with notable impact in drug discovery and target identification [250, 251]

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