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While insulins and GLP-1RAs have been considered equally effective at reducing HbA 1c [41, 42], a more recent meta-analysis reported that long-acting, once-weekly GLP-1RAs (exenatide and dulaglutide) achieve significantly greater reductions in HbA 1c than basal insulins such as insulin detemir, insulin glargine and insulin degludec [43]

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