GLP-1 Monotherapy Exenatide Exenatide (Byetta, Bydureon) was the first approved GLP-1 analogue in 2005, a synthetic form of the naturally occurring peptide exendin-4 first isolated from Heloderma suspectum (Gila Monster) lizard venom in 1992 [25]
While tirzepatide (Zepbound and Mounjaro) currently leads in terms of average weight loss in approved medications, CagriSema could become a strong competitor once Phase 3 results are released
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While a 120 mg once daily dosage was shown to be effective, there is no evidence that doses greater than 60 mg/day confer additional benefit
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