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We removed extreme values lying more than three times the IQR beyond the boundaries of the interquartile range, for that site, and site-normalised all values by subtracting the site median from each value and dividing by the median absolute deviation (MAD)

Carr, A., and B

Johnson, D.W

Brain Behav Immun 47:2434 Sorgdrager FJH et al (2019) Tryptophan metabolism in inflammaging: from biomarker to therapeutic target