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Clinical monitoring and patient safety advice includes: Gastrointestinal symptoms : Patients should report severe or persistent nausea, vomiting, or abdominal pain, which may indicate pancreatitis (a warning in tirzepatide labeling) or require dose adjustment

This means they are not subject to the same rigorous pre-market safety and efficacy testing required of licensed pharmaceutical products

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Then, came liraglutide, which lasts all day, but even once-a-day injections can be a pain

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Immunologically, there were no significant differences in sIgE, IgG4, PBMC cytokine production, or basophil activation between groups [38]