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The dose was increased in weekly intervals by 0.6 mg to reach 1.2 mg or 1.8 mg for patients randomized to these higher doses

The lawsuit said about four months later, Engel was diagnosed with nonarteritic anterior ischemic optic neuropathy, or NAION, a condition in which a loss of blood flow to the optic nerve causes sudden and irreversible vision loss

Gene ontology analysis of miRNA targets revealed significant enrichment in pathways related to inflammation, cell cycle regulation, and various neuronal and glial-neuronal structures at both timepoints