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The LES is a ring of muscle at the bottom of your esophagus that acts as a one-way valve

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Interestingly, the increased relative abundance of the probiotic Akkermansia may also mediate this effect [76]

[25] Murine cells overexpressing the NADase CD38 consumed less oxygen, had higher lactate levels, and had abnormal mitochondria, including traits like missing or enlarged cristae, which lends more proof of NAD+s role in promoting mitochondrial and metabolic health

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