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We would like to express our sincere gratitude to FigDraw for providing their exceptional software, which greatly facilitated the creation and visualization of the figures in this study

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This timeframe aligns with the gradual nature of biological processes, which occur over weeks to months, not days

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Furthermore, most preclinical studies have used short-term high-glucose or db/db mouse models, which fail to recapitulate the chronic, progressive nature of human DN (e.g., long-term fibrosis and comorbidity-associated complications)

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