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The retina plays an important role in visual transduction, with retinal photoreceptors and RPE cells involved in visual formation

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Furthermore, a study revealed that liver-specific Zip8 KO mice exhibited significant decreases in systemic Mn levels under both Mn-rich and Mn-depleted conditions, indicating that hepatic ZIP8 mediates Mn reabsorption from bile to help maintain systemic homeostasis (Powers et al., 2023)

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In terms of intrinsic oxysterol biosynthesis within CD8 + T cells, tumor-derived prostaglandin E2 (PGE2) downregulates cholesterol-25-hydroxylase (CH25H) via the transcription factor ATF3, resulting in trogocytosis-related apoptosis by reducing essential 25-hydroxycholesterol [75]