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In brief, each nanoparticle formulation was added sequentially to 10 mL of deionized water, followed by the addition of H 2 O 2

Freeze-thaw cycles and cold methanol/water were used to extract the intracellular metabolites from the quenched cell pellets according to protocols described by Smart et al

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However, it is regrettable that clinical research in this area remains blank at present