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In the landmark 68-week STEP1 obesity trial, participants on 2.4mg recorded a mean body-weight reduction of 14.9%, versus 2.4% on placebo[1]. 50% lost 15% or more of their body weight, and 69% lost at least 10%[1]

One theory is that removing certain plant compounds (like lectins, oxalates, or gluten) reduces inflammation in sensitive individuals

Smedman et al

Stop all binders 3 days before urine testing

It is part of the incretin system , which enhances insulin secretion after meals

If your kidney markers spike after a particularly rough week of GI side effects , rehydrate aggressively and retest in 1-2 weeks before drawing conclusions