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In summary, improving obesity, hirsutism, acne, and other related physical symptoms plays a crucial role in the management of adolescent patients with PCOS

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23 All Gram-positive bacteria are intrinsically resistant to aztreonam, as they do not have penicillin-binding proteins (PBPs) that bind to aztreonam

Mutations in genes involved in mismatch repair result in a significant prevalence of microsatellite instability, which acts as a biomarker for vulnerability to immune checkpoint inhibitors (143)