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A large US prospective study, which followed 525,488 subjects, ages 50 to 71 years between 1995 and 2006, correlated higher intakes of dietary folate, supplemental folic acid, and total folate (diet and supplements combined) with decreased colorectal cancer (CRC) risk (124)

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In another study, male rats were given diets high in gluten and casein and it was reported that diets rich in gluten and casein may synergistically exacerbate dysbiosis by worsening leaky gut syndrome, by affecting the brain through the gut-brain axis

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