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The TRIUMPH-4 Phase 3 trial in obesity with knee osteoarthritis later reported 28.7% mean weight loss at 68 weeks with retatrutide 12 mg/week, and identified a dose-related dysesthesia (nerve-tingling) signal in 8.8% of 9 mg and 20.9% of 12 mg patients (Bays et al., 2025)

The CVS phenotype was obviously excluded to avoid a circular argument

Lillys Taltz (Ixekizumab) and Zepbound (Tirzepatide) Used Together Delivered Superior Efficacy in First-of-Its-Kind Phase 3b Trial for Adults with Active Psoriatic Arthritis and Obesity or Overweight

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