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On July 31, 2025, ASTP/ONC issued a notice of enforcement discretion regarding the electronic case reporting certification criteria under the ONC Health IT Certification Program

Birsoy K, Wang T, Chen WW, Freinkman E, Abu-Remaileh M, Sabatini DM

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J Am Acad Dermatol 45 (5): S183-7 (2001) Isotretinoin is metabolized in the liver by the cytochrome P-450 (CYP) microsomal enzyme system, principally by CYP2C8, CYP2C9, CYP3A4, and CYP2B6 isoenzymes, to several metabolites (e.g., 4-oxo-isotretinoin, retinoic acid [tretinoin], and 4-oxo-retinoic acid [4-oxo-tretinoin])

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The current state of eukaryotic DNA base damage and repair