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Advanced PCa refers to instances where the malignancy has metastasized beyond the prostate to adjacent tissues, lymph nodes, or remote organs, necessitating systemic treatment modalities

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Clinical manifestations of PLS patients suggest that palmoplantar hyperkeratosis and severe periodontitis occur only when DPP1 function is nearly completely absent, indicating that extremely high levels of inhibition are needed for obvious related clinical symptoms

H.HirayamaT.SekidoY.ToyokuniS

Epub 2005 Nov 18

Ensure you are using the right skin care products, and talk to the Dermatologist for more evaluation and management