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Dihexa significantly decreased levels of pro-inflammatory cytokines including interleukin-1 (IL-1) and tumor necrosis factor- (TNF-), both implicated in synaptic dysfunction and neuronal death in Alzheimer's disease

Although these t 1/2 values were not significantly different from the t 1/2 of peptide 1 (3.6 h), statistical significance was obtained at the 4 h time point for these three hybrids demonstrating their lower stability (Supplementary Fig

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Data sharing statement The datasets generated and analyzed during the present study are available from the corresponding author upon reasonable request

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