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We have identified a glycoprotein DKK3 specifically expressed in the liver tumor area by CAFs and we aim to investigate the potential of genetic or therapeutic suppression of DKK3 in controlling the liver cancer progression
Metabolomic analysis was conducted for the liver tissue and serum samples and transcriptome of the liver tissue was also analyzed via RNA-seq
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Benveniste MF, Moran CA, Mawlawi O, Fox PS, Swisher SG , Munden RF, Marom EM
In parallel, efforts are underway to identify early biomarkers, including those based on cerebrospinal fluid (CSF), peripheral blood, imaging modalities, and multi-omic signatures, to enable earlier intervention, before extensive neuronal loss has occurred