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In the current study, the Bern University team analysed data from the US Food and Drug Administration (FDA) Adverse Event Reporting System, a post-marketing, open-access pharmacovigilance database

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Critical limitations identified in the systematic review include predominant use of small rodent models (primarily rats), short follow-up periods relative to human healing timelines, variable dosing regimens complicating dose-response assessment, and lack of standardized outcome measures across studies

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Development 130 , 26232632 (2003)