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About 37% of patients who persist in smoking after apparent cure of their cancer will develop second cancers of the mouth, lips, tongue, and throat compared with only 6% of those who stop smoking

Constituent analyses of smoke or aerosols from these products integrated with cell culture and animal studies to identify biomarkers of human exposures and disease, have provided initial insight into their potential toxicity 6-8

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metabolic enzymes [p53-induced glycolysis and apoptosis regulator (TIGAR) and glucose transporters] that contributed to cancer metabolic switch can be inhibited 11