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Nicotine Tob Res 20:173182 Mathis C, Poussin C, Weisensee D, Gebel S, Hengstermann A, Sewer A, Belcastro V, Xiang Y, Ansari S, Wagner S, Hoeng J, Peitsch MC (2013) Human bronchial epithelial cells exposed in vitro to cigarette smoke at the airliquid interface resemble bronchial epithelium from human smokers

In this study, there were significantly higher ( P = 0.002) nicotine levels in smokers predicted by their genotype to have low CYP2A6 metabolism compared to normal metabolizers

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Experts say it messes up the human immune system