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Large epidemiological studies in the UK (Doll et al., 2005

Compared to nicotine replacement, the disproportionality results (OR (95% CI)) were varenicline 8.4 (6.810.4), and bupropion 2.9 (2.33.7). Their conclusions: Varenicline shows a substantial, statistically significant increased risk of reported depression and suicidal/self-injurious behavior

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If you're inconsistent in drag lengths, calculating the nicotine per puff might not be useful