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Year 3 The MoCA was administered at year 3, significant group difference persisted for MoCA Total score, MoCA Visuospatial Domain score and MoCA Memory Domain score (Table 2)

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For research purposes, de-identified data are accessible upon application through the NHIS Big Data Platform ( Applicants are required to submit a research proposal (including study aims, cohort definition and a data specification), documentation of institutional review board approval, and other materials requested by NHIS

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1 2 Merged to form Imperial Tobacco in 1901